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L-Glutathione is the oxidized form of glutathione and serves as an important indicator of cellular oxidative stress levels

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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

A total of 58 subjects who consented to join the study were randomized into two groups using block randomization stratified by sex