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Journal reference: Klausen MK, Justesen SK, Pedersen JN, et al

If you have type 2 diabetes, GLP-1 medications address both weight and blood sugar, making them the clearly superior option

This could mean the medicine may not work as it is supposed to

Key highlights A biweekly or every other week dosing schedule is becoming popular as an off-label maintenance strategy to sustain weight loss and metabolic benefits

That number is not just large in absolute terms, it is the largest weight-loss signal ever reported in a randomized Phase 3 trial of a GLP-1-class compound, and it arrived with additional secondary findings that reframe what "GLP-1 therapy" could eventually mean: a 75.8% reduction in osteoarthritis pain, a roughly 20% drop in LDL cholesterol, and a 72% reversal rate of prediabetes to normoglycemia in the affected subpopulation