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Ong, M., Yeruva, S., Sailer, A., Nilsen, S

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Analysis of CSF biomarkers revealed that IL-6 and GFAP levels increased from baseline to post-treatment, coinciding with a trending decrease in cytokines and chemokines associated with senescence

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172,173 Significant benefits for obesity-associated diseases are also being reported (Table 5) including reduced heart failure events at 104 weeks of follow up (hazard ratio [HR] 0.62 compared to placebo), 110 improved management of obstructive sleep apnea at 52 weeks, 111 and improved management of metabolic-dysfunction associated steatohepatitis (MASH) with a decrease of 1 fibrosis stage with no worsening of MASH at 52 weeks