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FIGURE 4 FIGURE 5 3.3 L-carnitine counteracted lenvatinib-induced protein synthesis inhibition in C2C12 myocytes We have shown that lenvatinib inhibits global protein synthesis in C2C12 myocytes at concentrations 100 nM, which is equivalent to the trough plasma concentration in patients with HCC (Supplementary Figure S1)

107 These functions stem from its ability to interact with a diverse range of molecules, such as matrix components, growth factors, protease inhibitors, cytokines, chemokines, and adhesion molecules, through both specific and non-specific saccharide domains along its chains

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