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Early evaluation allows for dosage adjustments or discontinuation if necessary

Chronic or repeated use of PSYs raises unanswered questions: Could tolerance to the psychological effects develop (perhaps beneficially allowing higher doses with less hallucination), or conversely might there be tachyphylaxis to the anti-inflammatory effects

Fever or chills

Proactive monitoring of both B12 and glycaemic status particularly in higher-risk groups is the most effective way to ensure that neither condition is inadvertently overlooked or mismanaged

You could have anemia, thyroid dysfunction, or another condition that requires specific treatment