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Deficient ARSA activity leads to the accumulation of sulfatide glycolipids, which leads to demyelination of central and peripheral nervous systems, and thus causes severe neurological dysfunctions including motor dysfunction, developmental delay, hyperactivity, lack of communication, coordination, speech problems, behavioral disturbance, and in worst-case scenario it may lead to death [6,7,8,9]

I would like to thank Paris Rich Bingham and Sebastian Butts for research assistance, and Rasa Siniakovas and Chris Miller for editorial assistance

Nicotinamide riboside-driven modulation of SIRT3/mtROS/JNK signaling pathways alleviates myocardial ischemia-reperfusion injury

The gradual loss of melanocytes and melanocyte stem cells seems to be a natural part of the ageing of the hair and scalp system

Using synthetic membranes imitating human skin or live-skin equivalents is also essential as these models eliminate the need for human or animal tests and hence improve the methods screening potential