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Introduction# CagriSema (cagrilintide + semaglutide, Novo Nordisk) and tirzepatide (Eli Lilly) represent the pinnacle of next-generation obesity pharmacotherapy, both achieving approximately 20% weight loss through different dual-mechanism approaches

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Critical Gaps and Limitations Across all peptides reviewed, several critical limitations persist: Zero Dementia Prevention Trials: All existing evidence addresses treatment of existing impairment