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Some of these GSTs are overexpressed in cancer cells 11, 12 , suggesting that tumors could be selectively vulnerable and be targeted with prodrugs activated by the overexpressed enzyme
Int J Biometeorol
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In gastric and colorectal cancer, high CHAC2 expression leads to reduced glutathione, elevated intracellular Ca 2+ and increased ROS, resulting in inhibited tumor growth, proliferation and migration
Candidate measures include fasting insulin and HOMA-IR, leptin and ghrelin, and inflammatory cytokines, alongside functional-imaging readouts of VTA/NAc reactivity to food cues
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