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The benefit was not observed in all-cause death (HR 0.99, 95% CI 0.841.15), hospitalization for heart failure (HR 1.04, 95% CI 0.891.22), cardiovascular death (HR 0.95, 95% CI 0.791.16), myocardial infarction (HR 0.88, 95% CI 0.711.08), stroke (HR 1.03, 95% CI 0.751.43) and death or hospitalization for HF (HR 1.07, 95% CI 0.781.46)

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Treatment begins at a low starting dose and is titrated upward over several weeks or months under medical supervision until a therapeutic maintenance dose is reached

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de Villiers WJ, van der Westhuyzen DR, Coetzee GA, Henderson HE, Marais AD