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While animal and in vitro studies have examined its activity, large-scale human clinical trials are limited, and its full safety and efficacy profile has not been established

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IL-22-mediated regulation of CXCR2 + neutrophils is a crucial pathogenic pathway in UC, suggesting that the core chemokine module is conserved in colitis development, possibly through signal transducer and activator of transcription 3 (STAT3) signaling [94]