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Kopetz S, Yoshino T, Kim TW, Wasan HS, Cutsem EV, Ciardiello F, Maughan TS, Eng C, Yaeger R, Desai J, Zhang X, Usari T, Mori A, Tabernero J

Notably, a study in A plaque-bearing Tg2576 mice, initiated at 14 months of age, showed no significant impact on relieving oxidative damage, even with elevated plasma melatonin levels [165]

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Such co-expression to produce separate proteins can be achieved, for example, using an internal ribosome entry site (IRES) or a self-cleaving peptide to link the genes [47]