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The herein investigated jr PPO1 has an asparagine (Asn240) as the 1 st activity controller and a leucine (Leu244) as the 2 nd activity controller (Fig

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In the agonist-bound structures, GN helices interact with ICL3 through Y385 GH5 , but this interaction is not found in the ligand-free GLP-1R and GCGR structures and greatly reduced in that of GIPR (Supplementary Fig

Shin D, Kim EH, Lee J, Roh JL