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Restart timing remains unsettled because trials have not measured re-titration after a prolonged stop

The first layer should focus on biodistribution: local or lesion-preferring delivery is likely to yield the greatest gain in therapeutic index

The medication should be transported in an insulated cooler with ice packs if refrigeration will not be available during travel, taking care to prevent direct contact with ice to avoid freezing

Disease interpretation should therefore connect the glutathione readout to mechanism and phenotype rather than treating it as a stand-alone diagnostic marker

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