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1 Patients able to climb 2 flights of stairs are likely to be low risk and use of PDE5 inhibitors is safe

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The peptide works by promoting the upregulation of actin, a protein that forms the cytoskeleton of cells and is essential for cell movement and structure

Also, it opposes the nowadays aggressive wound management if it considers in fistulas healing mostly local skin protection (Orangio, 2010

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