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This is a double-blinded, randomized controlled trial that evaluated the change in HbA1c at 26 weeks with placebo compared with oral semaglutide at doses of 3 mg, 7 mg and 14 mg (1:1:1:1) in 703 adult patients with untreated type 2 diabetes mellitus (T2DM)
Feeling cold while taking GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound)the latter being a dual GIP/GLP-1 receptor agonistis something many patients report anecdotally, though it is not listed as an official adverse effect in FDA-approved labeling for these medications
Route Topical / transdermal Published Dose Context Marketed by some clinics and compounders, but no published human exposure data was identified in FDA's December 2024 evaluation
Warmer temperatures can speed up bacterial growth, especially if the medication has been left out for a prolonged time
