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When to Contact Your Provider About Itching Minor, localized itching at the injection site that resolves within hours is common and typically does not require intervention beyond site rotation

A clinical trial with 2,000 adults without diabetes who took weekly semaglutide injections with a healthy diet and exercise found that: Participants lost an average of 4% of their initial body weight after 8 weeks on semaglutide

These are averages from the 2.4 mg dose group, so researchers still titrating through 1.0 mg might see slightly less, but the trajectory is clear

So we tapped experts for clarity

At 5mg/mL, 20 units equals 1mg