The Semaglutide cohort compared to the non-GLP-1RA anti-obesity medications cohort was older, had a lower prevalence of adverse socioeconomic determinants of health, mental disorders, and substance use disorders, and a higher prevalence of morbid obesity, T2D and obesity-associated comorbidities
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The positive and negative opposing regulation of growth hormone by GHRH and somatostatin, respectively, creates a rhythmic-circadian pattern of GH secretion
In summary, given the wide array of currently available DMTs with potential to promote and treat cancer, it is important for clinicians to be aware of the risks and benefits of prescribing these agents to MS patients, particularly to patients with a history of cancer