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The slightly higher serious adverse event rate with tirzepatide in SURPASS-2 has not raised safety concerns in subsequent, larger trials

The HR for NAION among new users of semaglutide was not different compared with that of the non-GLP-1 receptor agonist drugs using the sensitive NAION definitionempagliflozin (HR: 1.44), sitagliptin (HR: 1.30), and glipizide (HR: 1.23)

Significant increases in GDH levels have also been observed in the rat cerebellum in the late postnatal stage, an increase that is believed to be a reflection of synaptogenesis and neuronal development (Wolf and Schnzel, 1987

For context, every 1% reduction in LDL cholesterol correlates with roughly a 1% reduction in cardiovascular event risk, meaning tirzepatide's lipid effects translate directly to measurable heart health benefits

Your doctor might also give you fluids through an IV if you are very dehydrated