glp-1 and lupus Drugs Show Benefits in Patients With Diabetes At Lupus LA’s #LatestOnLupus Conference

5m and Supplementary Fig

Variants in GLP1R (the GLP-1 receptor itself), GIPR (rs1800437 is the headline variant for differential GLP-1 response), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

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While the supplement successfully and dramatically improved the patients' blood inflammatory markers (lowering the pro-inflammatory AA:EPA ratio), it did not result in statistically significant improvements in clinical symptoms like fatigue or shortness of breath

In a second study, researchers from the University of Texas Medical Branch, Houston, TX, used the TriNetX database to identify adults with obesity who underwent TAVR from January 2020 to January 2025