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Coffee consumption has been associated with reduced risks of coronary heart disease, heart failure, arrhythmias, stroke, cardiovascular disease, and all-cause mortality 45,46
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We do not know the optimal human dosing, long-term safety profile in humans, or whether animal results translate directly to human outcomes
This authoritative observation cements the understanding that POTS and related autonomic disorders are not simply mechanical circulatory issues, but are deeply rooted in underlying metabolic and mitochondrial deficits that require targeted nutritional intervention to resolve
Nat Rev Endocrinol (2018) 14(5):30116
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