The FDA and cardiovascular specialists express concern about dual therapy because combined appetite suppressants may increase blood pressure, heart rate, and cardiac workload
Immunogenicity: The FDA classified BPC-157 in Category 2 for bulk drug substances, citing possible safety issues in compounding (immunogenicity, impurities, and insufficient safety evidence for suggested administration routes)
However, as research continued, erythrocytes were shown to affect vascular tone, immunity, redox homeostasis, and blood clotting
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Therefore, a direct measurement of the lean body mass must be performed to advocate for this effect