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Naltrexone and bupropion work together in your brain to help reduce appetite and manage cravings

The dysesthesia signal illustrates why this matters

MELATONIN SYNTHESIS AND METABOLISM Melatonin Synthesis Melatonin (N-acetyl-5-methoxytryptamine) is synthesized within the pinealocytes from tryptophan, mostly occurring during the dark phase of the day, when there is a major increase in the activity of serotonin-N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT), responsible for the transformation of 5-hydroxytryptamine (5HT, serotonin) to N-acetylserotonin (NAS) (Figure 1)

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Mild nausea within 2448 hours of restart is common and usually resolves as your body readjusts