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While no direct pharmacokinetic interaction has been established between GLP-1 receptor agonists and thyroid hormone replacement, the delayed gastric emptying effect of these medications could theoretically affect absorption of oral medications, including those with a narrow therapeutic index like levothyroxine

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GLP-1RA Risks and Prescribing Considerations GLP-1RAs are generally well tolerated, but thoughtful prescribing and patient counseling remain essential