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The clinical significance arises when B12 is elevated without a clear exogenous explanation

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Here are the B12 overdose symptoms: Skin rashes gastrointestinal issues (like nausea and diarrhea) Anxiety High blood pressure Heart palpitations

Intrinsic Factor Inhibiting Conditions Conditions such as autoimmune disease or pernicious anemia cause an inability to make the intrinsic factor that is essential for Vitamin B-12 absorption

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