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Indeed, loss of glutathione peroxidase 4, a oxidation-resistant selenoprotein that utilizes GSH, leads to lipid peroxidation and subsequent ferroptosis, which is also found in epilepsy models ( The NADPH oxidase (NOX) family of enzymes is another relevant major source of ROS in the context of epilepsy as evidenced by activation of NOX2 by kainate-induced SE ( 2 ), which then undergoes primarily enzymatic dismutation to H 2 O 2

Clinical trials are conducted under a wide range of conditions

This conditional approval further acknowledges the high unmet need for effective pharmacological interventions in MASH

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That could be thanks to reduced inflammation, improved gut health, or better stress regulation