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A very small risk of a side effect called Paradoxical Adipose Hypertrophy (PAH) is associated with cryolipolysis - - it is estimated that this risk is about 1 in 4000 (0.025% risk)

Increase of fat oxidation and weight loss in obese mice by chronic treatment with human growth hormone or a modified C-terminal fragment

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While mild tiredness may be manageable with lifestyle adjustments, certain presentations of fatigue warrant prompt medical evaluation