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One challenge for scientists working in the area of drug discovery is accurately and rapidly predicting the metabolic susceptibility of aniline-containing candidate drugs to the actions of serine hydrolases, the main enzymes responsible for amide hydrolysis

[DOI] [PubMed] [Google Scholar] 68.Herzenberg LA, De Rosa SC, Dubs JG, et al

As expected, we observed a depletion of several sgRNAs targeting the control genes, specifically the metal-detoxifying genes (Fig 2BD)

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