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This effect might result from increased regional blood flow, initial vasodilation, or inhibition of water and anion reabsorption in the kidneys (272, 273)
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The clinical significance of this effect is not fully characterized, but some providers recommend that women on oral contraceptives switch to a non-oral method (patch, ring, IUD, implant) when starting GLP-1 therapy, or use backup contraception during the titration period
Their mode of action may not be directly related to an AT mechanism but may involve other effects, as some of them (including PBN) were shown to release NO (nitric oxide), which can inhibit ROS-producing enzymatic activity
Geoff Geredien (00:39:26): Yeah, absolutely
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