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Atherosclerosis, one of the main risk factors of CVD, consists of the initial endothelial cell injury followed by lipoprotein deposition, inflammatory reaction, and smooth muscle cell cap formation 2

FIGURE 1 FIGURE 2 In this review, we integrate recent advances in the understanding of osteoarthritis pathophysiology, spanning cartilage, subchondral bone, synovium, and peri-articular tissues, to highlight their interconnected roles in disease initiation and progression