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A 2023 review in Frontiers in Physiology noted that mitochondrial-derived peptides like MOTS-c represent a functionally separate class from growth-hormone-axis compounds such as Tesamorelin underscoring why comparison, rather than substitution, is the right framework for evaluating them

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The compound was proposed as an under-the-skin injection to treat narcolepsy and opioid withdrawal, yet clinical studies used an intravenous route, which puts an injection directly into a vein

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