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Under conditions of metabolic stress, it migrates to the cell nucleus, where it activates a suite of genes governed by AMPK (AMP-activated protein kinase), the master cellular energy sensor

Initial excitement fades, and obesity continues to rise

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Although in vivo testing to determine the safety and efficacy of JWU-A021 still remains to be achieved, cyclohepta[ b ]indoles based on the structure of JWU-A021 might find a role in therapeutics as a new class of GLP-1 secretagogues