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Unmet Needs and Whitespace Opportunities Despite the remarkable clinical and commercial success of GLP-1 agonists, significant unmet needs persist that define the whitespace for next-generation innovation

10.1038/jid.2012.230 28 OujiY.YoshikawaM.MoriyaK.NishiofukuM.MatsudaR.IshizakaS

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122 Two PCOS mouse models were developed using prenatal androgenization (via DHT administration to pregnant dams on gestational days 1618) and postweaning androgenization (via subcutaneous DHT implants at day 21), followed by high-fat diet exposure and 28-day treatment with GLP-1-based mono- and multi-agonists or metformin starting on postnatal day 80, with outcomes assessed at day 108

Others have continued to supply existing customers with compounded GLP-1 drugs, but have stopped taking on new ones