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Compared to the group with normal renal function, the mean exposure of semaglutide appeared to be higher in the group with mild renal impairment (estimated ratio: AUC 24,Day10 1.37 [90% CI 0.912.06] and C max,Day10 1.39 [0.932.06]), whereas lower exposure was observed in the group with severe renal impairment (estimated ratio: AUC 24,Day10 0.61 [90% CI 0.420.88] and C max,Day10 0.61 [0.420.87])

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Current medical literature, however, does not support it as a blanket approach

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In each analysis, 20 L of a sample volume was injected, and a mobile phase of 80% acetonitrile aqueous was used