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doi: 10.1016/s0009-2797(01)00153-3

10.1093/humrep/17.3.659

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Despite promising preclinical findings, clinical translation of neuroprotective strategies has been limited by persistent conceptual and methodological challenges

Sample size was limited by the need to perform exercise tests on all participants in a very narrow time frame in terms of time of day (between 0600 and 0900) and date (3 weeks before the half-marathon and 2 weeks before the half-marathon)