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Animal model studies have suggested that GLP-1RAs may cause pancreatitis and exocrine dysplasia, but in the large RCTs and a meta-analysis, GLP-1RAs did not increase the risk of pancreatitis or pancreatic cancer [82,83]

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Similar to BMIS, microbiota composition and dietary variables alone performed poorly, explaining on average 2% and 1% of TMAO variance, respectively, in T2D and IHD individuals (Fig

MiR-122 inhibition leads to decreased plasma cholesterol and triglyceride levels associated with altered lipids biosynthesis and increased FAO

Insurance coverage for these therapies is often limited or inconsistent, which can restrict individualized care