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But with any supplement that contains so many ingredients (more than 70 key actives across both products), its nigh impossible to avoid intolerances and interactions entirely

2022 Jun;60(2):135-144

Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage

PMID: 72 RettedalEAIlesanmiOyelereBLRoyNCCoadJKrugerMC

Cu is also a component of several other enzymes, for example, ceruloplasmine and cytochrome oxidase (LAbbe and Friel, 1992)