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These OH radicals can further abstract electrons from unsaturated fatty acids (FAs), creating unstable lipid radicals that initiate a self-propagating chain reaction of lipid peroxidation, ultimately leading to lysosomal membrane rupture and leakage [182]

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31 Lastly, genetic profiling did not reveal BRAF- V600E mutations, which are commonly associated with metastatic spinal melanoma and may help differentiate MMNSTs from other melanotic spinal tumors like metastatic spinal melanoma

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