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If left unchecked, this can progress to autoimmune disorders, where measurable tissue damage occurs

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This different entry point changes which downstream proteins get activated

Multiple studies have shown that it was possible to decrease the expression of the UBE3A NAT, rescue the sense UBE3A expression, and ameliorate cognitive and behavioral phenotypes in a mouse model of AS through the RNAse-mediated degradation [59, 110]