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Lab Invest 92 , 396410 (2012)

TMAO has also been found to promote plaque formation by stabilizing and adjusting the assembly of the amyloid- (A) peptide (Yang et al., 1999) and fibrillation of tau protein by inducing the secondary structure formation at the C terminus in vitro (Scaramozzino et al., 2006)

Major metabolites found were trimethylamine N-oxide, primarily in urine (8% to 49% of the administered dose) and [3H]--butyrobetaine, primarily in feces (0.44% to 45% of the administered dose)

This lends support to the belief that substances from the intestine were involved in the postprandial control of insulin secretion, which was referred to accordingly as the incretin effect