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1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older ( Ferroptosis, first reported in 2012, is a novel form of cell death distinct from classical apoptosis, pyroptosis, and necrosis ( Due to the possible critical role of ferroptosis in OA, there has been a surge of interest in elucidating its molecular mechanisms and exploring potential therapeutic strategies

G., Katzenellenbogen, B

Similarly, PRR11i increases LPO and disrupts the mitochondrial morphology regulated by DHODH, thereby promoting ferroptosis in GBM cells and enhancing their chemosensitivity to temozolomide (TMZ)[42]

Anorexia nervosa and osteoporosis: a possible complication to remember

Nature 526 , 6874 (2015)