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DeFronzo R, Bergenstal R, Bode B, et al

However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule

Get to an emergency room immediately if you experience: sudden loss of bladder or bowel control, sudden severe weakness in both legs, saddle anesthesia (numbness in the area that would touch a saddle), or sudden severe weakness or numbness in both arms

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Hypertension is a well-established risk factor for cerebrovascular disease, which is itself a major contributor to vascular dementia and AD