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Cardiopulmonary Stress Frequent drinking can cause high or low blood pressure, irregular heart rate, and dehydration, all of which complicate anesthesia and post-operative monitoring

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Lee Kang-Woo,Park Je-Young (2007) Effect of basketball training on body composition, blood leptin, melatonin, and growth hormone levels according to positions in university female basketball players

Its typically defined by therapy gaps of 60 days or more, or when the Proportion of Days Covered (PDC) falls below 80%