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However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209
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A recent meta-analysis of 21 studies also reported a significant decrease in the odds for pregnancy and live delivery per cycle versus non-smokers, as well as a marked increase in the odds for spontaneous miscarriage and ectopic pregnancy
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