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For dry powder inhalation, mucolytics such as mannitol and sorbitol are recommended to improve particle penetration through mucus by osmotically drawing water into the airway surface, thereby hydrating and loosening the mucus gel layer 195
Animals Four-week-old male SD rats of specific pathogen-free (SPF) grade for experiments were obtained from Nanjing Qinglong-shan Animal Farm (SCXK(SU) 2017-0001, China)
[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Medhasi S, Pinthong D, Pasomsub E, Vanwong N, Ngamsamut N, Puangpetch A, Chamnanphon M, Hongkaew Y, Pratoomwun J, Limsila P, et al
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