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This risk posits a critical limitation on the therapeutic window for senolytic drugs like FOXO4-DRI, demanding a fine balance between efficacy and safety

Phytochemicals including quercetin, beta-caryophyllene, curcumol, boswellic acid, caftaric acid, some flavonoids and other secondary metabolites being a consequential component of numerous medicinal plants, have displayed a significant reduction in the levels of proinflammatory cytokines including TNF-, NFB, IL-1, NLRP3 inflammasome, IL-6, IL-2, matrix metalloproteinases etc

Supplementation with NAC, cysteine, and glycine has been shown to increase GSH levels.

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Research is ongoing, and while initial results are promising, its always vital to ensure safety and efficacy