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Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

pH level: 6.40 ~ 8.40

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Multiple other transporters and enzymes, including the availability of GSSG reductase, thioredoxins, and activity of glutathione transferases are also involved in maintenance of the intracellular GSH-GSSG balance, which could be evaluated in the future