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Optimal thyroid hormone replacement remains the foundation of treatment, but additional strategies may be appropriate for select patients who continue to experience weight-related challenges despite adequate thyroid management

The escalation typically started at 2 mg weekly for the first 4 weeks, then increased every four weeks in increments of 2 to 4 mg until the target research dose was reached

2018 Jun 22;360(6395):eaap8757

The Danger Zones : Above 86F (30C) : Rapid protein degradation At or below 32F (0C) : Freezingmedication must be discarded 3236F (02C) : High risk of accidental freezing