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Drug-induced lupus erythematosus: an update on drugs and mechanisms

Updated phase 3 titration pathway The phase 3 schedule uses the following escalation: Weeks 1-4: 2mg weekly Weeks 5-8: 4mg weekly Weeks 9-12: 8mg weekly Week 13+: Maintenance dose (4mg, 9mg, or 12mg depending on assignment) The introduction of a 9mg dose option is interesting

A formulation buffered at pH 7.4 with appropriate stabilizing excipients will last longer than one compounded at a lower pH without the same level of formulation science behind it

Wash your hands and attach a fresh needle

However, emerging lawsuits claim the drug caused an eye condition called non-arteritic anterior ischemic optic neuropathy NAION