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In a pentylenetetrazol (PTZ) kindling rat seizure model, suppression of the HMGB1/RAGE/TLR4 inflammatory cascade by administration of pentoxifylline resulted in reduced ROS levels, whilst also improving cognition, memory and hippocampal neuronal survival [54], suggesting that regulation of neuroinflammatory pathways has a positive downstream effect on OS

Kao et al., 2018)

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The de novo biosynthesis of sphingolipids, catalyzed by serine palmitoyltransferase, connects serine and mitochondrial alanine metabolism to membrane lipid diversity, a mechanism that could be exploited to induce tumor cell death under metabolic stress, such as in an amino acid-deprived microenvironment [126]

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