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Some of this work reached early human investigation: full-length Thymosin Beta-4 has been examined in clinical-stage research for indications such as dry-eye disease and wound healing, which gives TB-500's parent compound a somewhat broader human-research footprint than BPC-157 although the synthetic TB-500 fragment itself remains a research compound without approval

Vitamin B12 deficiency may increase the risk of infections, and vitamin B12 injections may help to boost the immune system

Pregnant or breastfeeding women should avoid BPC-157, as no studies evaluate its safety in these populations

Spermidine supplementation may also suppress aortic aneurysm formation and inflammation in a mouse model